Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 7/20 | 0.55 |
| ▸ | RORC | P51449 | 4/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28294857 | 0.83 | PTGS1 (0.49) | RORBRORCMAPK14PTGS1LMNA | |
| SCHEMBL7090488 | 0.80 | JAK2 (0.53) | RORBRORCRECQLGAASMN1; SMN2 | |
| SCHEMBL7182044 | 0.79 | GAA (0.55) | RORBRORCPTGS1RECQLGAA | |
| SCHEMBL746794 | 0.79 | LMNA (0.64) | MAPK14PTGS1LMNAGAACNR2 | |
| SCHEMBL6654597 | 0.79 | MAPK14 (0.69) | MAPK14GAASMN1; SMN2MAPK13MAPK12 | |
| SCHEMBL5566999 | 0.78 | NPFFR2 (0.45) | RORBRORCNR1H4JAK2TYK2 | |
| SCHEMBL2705305 | 0.78 | RECQL (0.65) | RORBMAPK14PTGS1RECQLLMNA | |
| SCHEMBL5172393 | 0.77 | MAPK13 (0.61) | RORBRORCMAPK14RECQLSMN1; SMN2 | |
| SCHEMBL28815055 | 0.77 | LMNA (0.62) | MAPK14PTGS1LMNAGAACNR2 | |
| SCHEMBL8989958 | 0.76 | GAA (0.53) | RORBMAPK14PTGS1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |
| EP-0966424-A1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998032730-A1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-07-30 | — | — | WO | disclosed |