Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | DDX3X | O00571 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27639139 | 0.87 | GAA (0.67) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL2791237 | 0.84 | MAPK13 (0.78) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL2789324 | 0.84 | MAPK13 (0.78) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL9480199 | 0.84 | MAPT (0.95) | MAPK14MAPTMEN1KMT2AGAA | |
| SCHEMBL5154269 | 0.84 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| Acetic Acid SCHEMBL5914600 | 0.83 | MAPT (0.78) | MAPTMEN1KMT2AGAAKDM4E | |
| SCHEMBL14982062 | 0.83 | MAPK13 (0.74) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL29196087 | 0.82 | MAPK13 (0.95) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL2742816 | 0.82 | MAPK13 (0.95) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL809316 | 0.82 | MAPT (1.00) | MAPTMEN1KMT2AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188388-C | Aminobenzophenones as inhibitors of interleukin and TNF | LEO PHARM PROD LTD (DK) | 2005-02-09 | — | — | CN | disclosed |
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |