SCHEMBL6654441

SCHEMBL6654441

Cc1[nH]c2ccc(OCC#N)cc2c1C(=O)OCc1ccccc1.N#CCBr

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.46
GABRA1 P14867 3/20 0.46
GABRG2 P18507 3/20 0.46
GABRB3 P28472 3/20 0.46
GABRA5 P31644 3/20 0.46
GABRA3 P34903 3/20 0.46
GABRA2 P47869 3/20 0.46
TRPM8 Q7Z2W7 1/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
KMT2A Q03164 2/20 0.43
NSD2 O96028 1/20 0.42
AS3MT Q9HBK9 1/20 0.42
MAPT P10636 6/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
TSHR P16473 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
MAPK1 P28482 1/20 0.42
ALOX5 P09917 1/20 0.42
HPGD P15428 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6315273 0.96 GAA (0.49) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL6315741 0.84 GAA (0.49) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL6316345 0.83 GAA (0.50) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL6314661 0.81 GAA (0.50) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL6656526 0.81 GAA (0.56) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL6315202 0.81 GAA (0.48) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL13309192 0.80 GABRA1 (0.67) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL6317769 0.80 GAA (0.49) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL6321136 0.80 GAA (0.54) GAAGABRA1GABRG2GABRB3GABRA5
SCHEMBL7827626 0.79 GAA (0.53) GAAGABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1377549-A1 FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR Millennium Pharmaceuticals, Inc. (US) 2004-01-07 EP disclosed
WO-2002072549-A1 FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR MILLENNIUM PHARMACEUTICALS, INC. (US) 2002-09-19 WO disclosed