SCHEMBL6654469

SCHEMBL6654469

C[C@@H]1CN([C@H](c2cccc(O)c2)c2ccccc2C#N)[C@@H](C)CN1Cc1nccs1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 1/20 0.38
OPRM1 P35372 1/20 0.38
OPRD1 P41143 1/20 0.38
OPRK1 P41145 1/20 0.38
SIGMAR1 Q99720 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6659217 0.84
SCHEMBL8030090 0.81 CYP1A2 (0.45) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6653135 0.81 CYP1A2 (0.45) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6653260 0.81 OPRD1 (0.42) OPRD1
SCHEMBL8081871 0.80 OPRD1 (0.58) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6932686 0.80 OPRD1 (0.58) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6657055 0.80 OPRD1 (0.45) OPRD1
SCHEMBL6653646 0.80
SCHEMBL6652556 0.78 CYP1A2 (0.38) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6923473 0.72 OPRD1 (0.44) OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0983251-B1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF PFIZER LTD (GB) 2004-06-23 EP disclosed
US-6514975-B1 Tetrazoles as selective agonists for the delta opioid receptor PFIZER INC 2003-02-04 US disclosed
EP-0983251-A1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF Pfizer Limited (GB) 2000-03-08 EP disclosed
WO-1998052929-A1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF PFIZER LIMITED (GB) 1998-11-26 WO disclosed