SCHEMBL6654487

SCHEMBL6654487

NC(C(=O)c1ccc(F)cc1)C(=O)c1cccnc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.54
ATM Q13315 1/20 0.54
CYP11B1 P15538 1/20 0.50
CYP11B2 P19099 1/20 0.50
F7 P08709 1/20 0.50
F3 P13726 1/20 0.50
SARM1 Q6SZW1 1/20 0.50
SIRT2 Q8IXJ6 1/20 0.50
SIRT6 Q8N6T7 1/20 0.50
SIRT1 Q96EB6 1/20 0.50
SIRT3 Q9NTG7 1/20 0.50
SIRT5 Q9NXA8 1/20 0.50
SIRT4 Q9Y6E7 1/20 0.50
GAA P10253 3/20 0.49
PTGS2 P35354 2/20 0.49
POLB P06746 1/20 0.49
EPHX2 P34913 1/20 0.48
ALDH1A1 P00352 1/20 0.47
APP P05067 1/20 0.47
HCAR3 P49019 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5288409 0.80 F7 (0.61) CYP11B1CYP11B2F7F3SARM1
Hydrochloric Acid SCHEMBL5787243 0.79 POLB (0.50) KMT2AATMCYP11B1CYP11B2GAA
SCHEMBL29691445 0.78 LTA4H (0.63) KMT2AATMCYP11B1CYP11B2F7
SCHEMBL7802228 0.78 LTA4H (0.63) KMT2AATMCYP11B1CYP11B2F7
SCHEMBL10841082 0.78 KMT2A (0.61) KMT2AATMCYP11B1CYP11B2F7
SCHEMBL27780057 0.78 F7 (0.62) CYP11B1CYP11B2F7F3SARM1
SCHEMBL28659975 0.76 F7 (0.60) CYP11B1CYP11B2F7F3SARM1
SCHEMBL11475710 0.75 POLB (0.52) KMT2AATMCYP11B1CYP11B2GAA
SCHEMBL27259251 0.75 F7 (0.58) CYP11B1CYP11B2F7F3SARM1
SCHEMBL9292468 0.74 ALDH1A1 (0.59) KMT2AATMCYP11B1CYP11B2F7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1432690-A2 IMIDAZOLE, THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF POLLAKIURIA OR URINARY INCONTINENCE Tanabe Seiyaku Co., Ltd. (JP) 2004-06-30 EP disclosed
WO-2002083111-A2 IMIDAZOLE, THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF POLLAKIURIA OR URINARY INCONTINENCE TANABE SEIYAKU CO., LTD. (JP) 2002-10-24 WO disclosed