Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653321 | 0.85 | DRD3 (0.48) | DRD3OPRM1 | |
| SCHEMBL6655150 | 0.85 | DRD3 (0.69) | DRD3OPRM1ACHE | |
| SCHEMBL11637435 | 0.84 | ACHE (0.61) | DRD3ACHE | |
| SCHEMBL27304227 | 0.81 | OPRD1 (0.57) | DRD3OPRM1 | |
| SCHEMBL11814580 | 0.80 | DRD3 (1.00) | DRD3OPRM1 | |
| SCHEMBL11813871 | 0.80 | DRD3 (1.00) | DRD3OPRM1 | |
| Profadol SCHEMBL160670 | 0.79 | ACHE (0.66) | OPRM1ACHE | |
| Bromide SCHEMBL11818169 | 0.79 | DRD3 (0.98) | DRD3OPRM1 | |
| Bromide SCHEMBL11812525 | 0.79 | DRD3 (0.98) | DRD3OPRM1 | |
| SCHEMBL6658571 | 0.78 | DRD3 (0.45) | DRD3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077940-B1 | 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6610711-B2 | 4-phenylpiperidines for the treatment of pruritic dermatoses | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |
| US-20030078282-A1 | Novel 4-phenylpiperidines for the treatment of pruritic dermatoses | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
| EP-1077940-A1 | 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059971-A1 | NOVEL 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 1999-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078282-A1 | Novel 4-phenylpiperidines for the treatment of pruritic dermatoses | HRH2, HRH4, HRH1 | DRD3 101/4885OPRM1 409/4885ACHE 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.