Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6654701 | 1.00 | OPRD1 (0.48) | OPRD1HRH1SLC6A2HRH2HTR2A | |
| SCHEMBL6654713 | 1.00 | OPRD1 (0.48) | OPRD1HRH1SLC6A2HRH2HTR2A | |
| SCHEMBL6658983 | 0.88 | HRH1 (0.52) | OPRD1HRH1SLC6A2HRH2HTR2A | |
| SCHEMBL6658977 | 0.88 | HRH1 (0.52) | OPRD1HRH1SLC6A2HRH2HTR2A | |
| SCHEMBL6658996 | 0.88 | HRH1 (0.52) | OPRD1HRH1SLC6A2HRH2HTR2A | |
| SCHEMBL6652027 | 0.88 | OPRD1 (0.50) | OPRD1USP2OPRM1OPRK1 | |
| SCHEMBL6652014 | 0.88 | OPRD1 (0.50) | OPRD1USP2OPRM1OPRK1 | |
| SCHEMBL6652019 | 0.88 | OPRD1 (0.50) | OPRD1USP2OPRM1OPRK1 | |
| SCHEMBL6656936 | 0.88 | OPRD1 (0.44) | OPRD1OPRM1OPRK1 | |
| SCHEMBL6656946 | 0.88 | OPRD1 (0.44) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983251-B1 | ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF | PFIZER LTD (GB) | 2004-06-23 | — | — | EP | disclosed |
| US-6514975-B1 | Tetrazoles as selective agonists for the delta opioid receptor | PFIZER INC | 2003-02-04 | — | — | US | disclosed |