Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7064839 | 0.84 | EPHX1 (0.44) | EPHX1NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL16824229 | 0.83 | EPHX1 (0.59) | EPHX1SMN1; SMN2L3MBTL1HPGDACHE | |
| SCHEMBL8382659 | 0.80 | EPHX1 (0.52) | EPHX1NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9258313 | 0.79 | GAA (0.44) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL28460826 | 0.78 | EPHX1 (0.46) | EPHX1NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL288938 | 0.78 | EPHX1 (0.59) | EPHX1SMN1; SMN2L3MBTL1HPGDACHE | |
| SCHEMBL11650927 | 0.78 | EPHX1 (0.53) | EPHX1SMN1; SMN2L3MBTL1HPGDACHE | |
| SCHEMBL7556363 | 0.77 | RAB9A (0.51) | EPHX1NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9177559 | 0.77 | EPHX1 (0.44) | EPHX1NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL855001 | 0.76 | EPHX1 (0.52) | EPHX1SMN1; SMN2L3MBTL1HPGDACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423167-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING QUINALDOYL-AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUTED HYDROCARBONS | Elan Pharmaceuticals, Inc. (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003020370-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING QUINALDOYL-AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUTED HYDROCARBONS | ELAN PHARMACEUTICALS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |