Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11608157 | 0.83 | GAA (0.42) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL355253 | 0.80 | GAA (0.55) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL6656435 | 0.79 | EPHX1 (0.48) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL16225032 | 0.79 | GAA (0.40) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL28578606 | 0.77 | LMNA (0.41) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL29173684 | 0.77 | GAA (0.41) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL15998069 | 0.77 | GAA (0.38) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL906813 | 0.76 | — | — | |
| SCHEMBL17280414 | 0.76 | LMNA (0.43) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL204875 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5385893-A | For magnetic resonance imaging | THE DOW CHEMICAL COMPANY (US) | 1995-01-31 | — | — | US | claimed |
| EP-2383280-A1 | Expression system for toxic ion channels, in particular ryanodine receptors | E. I. du Pont de Nemours and Company (US) | 2011-11-02 | — | — | EP | disclosed |
| US-7919623-B2 | Naphthyridine derivatives having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2011-04-05 | — | — | US | disclosed |
| US-20090227621-A1 | Naphthyridine derivatives having inhibitory activity against hiv integrase | SHIONOGI & CO., LTD. (JP) | 2009-09-10 | — | — | US | disclosed |
| US-5441924-A | Herbicidal substituted triazolinones | BAYER AKTIENGESELLSCHAFT (DE) | 1995-08-15 | — | — | US | disclosed |
| US-5385893-A | For magnetic resonance imaging | THE DOW CHEMICAL COMPANY (US) | 1995-01-31 | — | — | US | disclosed |
| US-5238902-A | Herbicidal substituted triazolinones | BAYER AKTIENGESELLSCHAFT (DE) | 1993-08-24 | — | — | US | disclosed |
| US-4492690-A | Phosphoric and thiophosphoric esters of 5(3)-hydroxypyrazoles exerting an insecticidal action | MONTEDISON S.P.A. (IT) | 1985-01-08 | — | — | US | disclosed |
| US-4459294-A | MITICIDES, NEMATOCIDES | MONTEDISON S.P.A. (IT) | 1984-07-10 | — | — | US | disclosed |
| US-4256902-A | FORMING AN ALKALINE SALT BY REACTING A HYDRAZINE WITH A B,B-DICHLORO-ACRYLOYL CHLORIDE, ACIDIFYING | MONTEDISON S.P.A. (IT) | 1981-03-17 | — | — | US | disclosed |
| US-4245106-A | IN THE PRESENCE OF ACETIC ACID | MONSANTO COMPANY (US) | 1981-01-13 | — | — | US | disclosed |
| US-4116673-A | HERBICIDES | MONSANTO COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4076938-A | Process for the production of 3-hydroxy-1,2,4-triazole derivatives | CIBA-GEIGY CORPORATION (US) | 1978-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227621-A1 | Naphthyridine derivatives having inhibitory activity against hiv integrase | PNP, CDKL1, ASNS | GAA 929/4885MGAM 1817/4885SI 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.