Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617192 | 0.91 | MAPT (0.43) | MEN1KMT2ANPC1RPS6KA2MAPT | |
| SCHEMBL6651951 | 0.88 | P2RY14 (0.41) | MAPTSMN1; SMN2LMNANAMPTHPGD | |
| SCHEMBL6619674 | 0.88 | NAMPT (0.43) | MEN1KMT2ANPC1MAPTLMNA | |
| SCHEMBL6617916 | 0.86 | NAMPT (0.44) | MEN1KMT2ANPC1RPS6KA2MAPT | |
| SCHEMBL6615885 | 0.86 | NPC1 (0.47) | MEN1KMT2ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6616574 | 0.85 | NR1H4 (0.42) | MEN1KMT2ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6651122 | 0.85 | NAMPT (0.40) | NAMPT | |
| SCHEMBL6615869 | 0.85 | NAMPT (0.41) | MEN1KMT2AMAPTSMN1; SMN2NAMPT | |
| SCHEMBL6616726 | 0.84 | SLC1A2 (0.38) | KMT2ANPC1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL6617914 | 0.84 | KMT2A (0.47) | MEN1KMT2ANPC1RPS6KA2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |