Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617916 | 0.94 | NAMPT (0.44) | NPC1ALDH1A1NAMPTPOLBRAB9A | |
| SCHEMBL6619674 | 0.93 | NAMPT (0.43) | NPC1ALDH1A1NAMPTRAB9AMEN1 | |
| SCHEMBL6619399 | 0.90 | MAPT (0.47) | NPC1ALDH1A1CYP1A2NAMPTPOLB | |
| SCHEMBL6618517 | 0.90 | KDM4E (0.45) | NPC1KDM4EALDH1A1NAMPTACKR3 | |
| SCHEMBL6616574 | 0.89 | NR1H4 (0.42) | NPC1KDM4EALDH1A1CYP1A2NAMPT | |
| SCHEMBL6615286 | 0.88 | RAB9A (0.51) | NPC1KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6617914 | 0.86 | KMT2A (0.47) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL6619639 | 0.86 | DRD2 (0.43) | NPC1KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6617192 | 0.86 | MAPT (0.43) | NPC1NAMPTACKR3POLBRAB9A | |
| SCHEMBL6656520 | 0.86 | MEN1 (0.40) | NPC1KDM4ENAMPTPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |