Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CRACR2A | Q9BSW2 | 5/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618867 | 0.91 | TP53 (0.41) | NAMPTEPHX2NR1H4MAPTSMN1; SMN2 | |
| SCHEMBL6605931 | 0.91 | ACKR3 (0.43) | EPHX2NR1H4MAPTSMN1; SMN2TRPV1 | |
| SCHEMBL6614591 | 0.89 | P2RY14 (0.42) | NAMPTMAPTSMN1; SMN2HDAC1CRACR2A | |
| SCHEMBL6615882 | 0.87 | NR1H4 (0.41) | NAMPTEPHX2NR1H4CRACR2ATRPV1 | |
| SCHEMBL6614876 | 0.87 | MEN1 (0.43) | NAMPTNR1H4MAPTHDAC1MEN1 | |
| SCHEMBL6624191 | 0.87 | CRACR2A (0.46) | NAMPTMAPTSMN1; SMN2HDAC1CRACR2A | |
| SCHEMBL6621456 | 0.86 | MEN1 (0.44) | NR1H4SMN1; SMN2CRACR2ATRPV1MEN1 | |
| SCHEMBL6619833 | 0.86 | TRPV1 (0.43) | NAMPTTRPV1 | |
| SCHEMBL6618415 | 0.86 | MEN1 (0.44) | NAMPTEPHX2NR1H4MAPTTRPV1 | |
| SCHEMBL6617294 | 0.85 | SLC1A2 (0.39) | NAMPTCRACR2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |