Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.66 |
| ▸ | MMP13 | P45452 | 8/20 | 0.55 |
| ▸ | MMP9 | P14780 | 7/20 | 0.55 |
| ▸ | MMP1 | P03956 | 6/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656852 | 0.88 | ADAM17 (0.66) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6657607 | 0.86 | ADAM17 (0.79) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL3947817 | 0.80 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6656577 | 0.79 | ADAM17 (0.60) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL7320579 | 0.79 | ADAM17 (0.60) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6655838 | 0.74 | ADAM17 (0.79) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6708417 | 0.74 | ADAM17 (0.56) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL7325352 | 0.74 | ADAM17 (0.79) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6753890 | 0.73 | ADAM17 (0.58) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6656569 | 0.72 | ADAM17 (0.54) | ADAM17MMP13MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |