Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.40 |
| ▸ | PPOX | P50336 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 11/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864570 | 0.89 | PLA2G2A (0.46) | TSPOPLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL5864634 | 0.83 | PLA2G2A (0.48) | TSPOPLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL5513723 | 0.83 | PLA2G2A (0.47) | PLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL6657470 | 0.83 | PLA2G2A (0.45) | TSPOPLA2G2APLA2G1B | |
| SCHEMBL6661790 | 0.82 | TSPO (0.42) | TSPOPLA2G2A | |
| SCHEMBL6657450 | 0.81 | PLA2G2A (0.43) | TSPOPLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL5864505 | 0.81 | PLA2G2A (0.47) | TSPOPLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL5864665 | 0.81 | PLA2G2A (0.51) | TSPOPLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL5864640 | 0.80 | PLA2G2A (0.58) | PLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL5864581 | 0.80 | PLA2G2A (0.44) | TSPOPLA2G2APLA2G1BPLA2G10PLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1438290-A1 | CYCLOHEPT B!INDOLE DERIVATIVES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-07-21 | — | — | EP | claimed |
| WO-2003016277-A1 | CYCLOHEPT`B!INDOLE DERIVATIVES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-02-27 | — | — | WO | claimed |