Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.54 |
| ▸ | MMP13 | P45452 | 15/20 | 0.54 |
| ▸ | MMP9 | P14780 | 13/20 | 0.54 |
| ▸ | MMP1 | P03956 | 12/20 | 0.54 |
| ▸ | MMP2 | P08253 | 4/20 | 0.53 |
| ▸ | MMP8 | P22894 | 3/20 | 0.53 |
| ▸ | MMP7 | P09237 | 2/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366235 | 0.74 | ADAM17 (0.68) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL7354960 | 0.72 | ADAM17 (0.80) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6708417 | 0.72 | ADAM17 (0.56) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6508472 | 0.72 | ADAM17 (0.76) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL3946372 | 0.71 | ADAM17 (0.77) | ADAM17MMP13MMP9MMP1MMP8 | |
| SCHEMBL6506403 | 0.71 | CA1 (0.65) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL14245317 | 0.71 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6499544 | 0.70 | ADAM17 (0.77) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL3940240 | 0.70 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6627004 | 0.70 | ADAM17 (0.58) | ADAM17MMP13MMP9MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | claimed |