Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.65 |
| ▸ | CA2 | P00918 | 6/20 | 0.65 |
| ▸ | CA7 | P43166 | 6/20 | 0.65 |
| ▸ | CA9 | Q16790 | 6/20 | 0.65 |
| ▸ | CA12 | O43570 | 5/20 | 0.65 |
| ▸ | CA4 | P22748 | 1/20 | 0.65 |
| ▸ | ADAM17 | P78536 | 14/20 | 0.63 |
| ▸ | MMP13 | P45452 | 8/20 | 0.60 |
| ▸ | MMP9 | P14780 | 6/20 | 0.60 |
| ▸ | MMP2 | P08253 | 5/20 | 0.60 |
| ▸ | MMP8 | P22894 | 4/20 | 0.60 |
| ▸ | MMP7 | P09237 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 5/20 | 0.55 |
| ▸ | MMP14 | P50281 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396462 | 0.84 | ADAM17 (0.65) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL14245317 | 0.83 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL6506400 | 0.83 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL6261998 | 0.83 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL3848565 | 0.83 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL7358814 | 0.83 | ADAM17 (0.72) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL5657792 | 0.83 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL6261997 | 0.81 | ADAM17 (0.61) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL15274643 | 0.81 | ADAM17 (0.58) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL7394845 | 0.80 | ADAM17 (0.60) | ADAM17MMP13MMP9MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | WYETH HOLDINGS CORPORATION | 2005-05-26 | — | — | US | disclosed |
| US-6716833-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, SEPSIS, AIDS, ULCERATIVE COLITIS, MULTIPLE SCLEROSIS, CROHN'S DISEASE AND DEGENERATIVE CARTILAGE LOSS. | WYETH HOLDINGS CORPORATION | 2004-04-06 | — | — | US | disclosed |
| US-20040033988-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | WYETH (US) | 2004-02-19 | — | — | US | disclosed |
| US-20030212049-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | WYETH (US) | 2003-11-13 | — | — | US | disclosed |
| US-20030008849-A1 | Acetylenic alpha -amino acid-based sulfonamide hydroxamic acid tace inhibitors | LEVIN JEREMY I (US) | 2003-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008849-A1 | Acetylenic alpha -amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, TASP1 | CA1 53/4885CA2 1627/4885CA7 647/4885 |
| US-20040033988-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, TASP1 | CA1 53/4885CA2 1627/4885CA7 647/4885 |
| US-20030212049-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, TASP1 | CA1 53/4885CA2 1627/4885CA7 647/4885 |
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, MMP12 | CA1 65/4885CA2 1547/4885CA7 615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.