Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656992 | 0.70 | SMN1; SMN2 (0.44) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL2070591 | 0.68 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| Methane SCHEMBL11401135 | 0.67 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL2632919 | 0.63 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL11243798 | 0.60 | KMT2A (0.54) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL2625570 | 0.59 | SMN1; SMN2 (0.65) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL16480329 | 0.59 | SMN1; SMN2 (0.59) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL2072581 | 0.59 | KDM4C (0.58) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL2072582 | 0.59 | KDM4C (0.58) | MEN1KMT2ASMN1; SMN2HTTTP53 | |
| SCHEMBL22521954 | 0.57 | SMN1; SMN2 (0.64) | MEN1KMT2ASMN1; SMN2HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412355-A1 | NEW PYRAZOLO(3,4-D)PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | AstraZeneca AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002567-A1 | NEW PYRAZOLO[3,4-D]PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | WO | disclosed |