Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070591 | 0.84 | MEN1 (0.56) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| Methane SCHEMBL11401135 | 0.83 | MEN1 (0.54) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| SCHEMBL6656983 | 0.70 | MEN1 (0.38) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| SCHEMBL2632919 | 0.69 | MEN1 (0.57) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| SCHEMBL2072581 | 0.68 | KDM4C (0.58) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| SCHEMBL2072582 | 0.68 | KDM4C (0.58) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| SCHEMBL11243798 | 0.66 | KMT2A (0.54) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| SCHEMBL2625570 | 0.65 | SMN1; SMN2 (0.65) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| SCHEMBL16480329 | 0.65 | SMN1; SMN2 (0.59) | SMN1; SMN2HTTMEN1KMT2ATP53 | |
| SCHEMBL22521954 | 0.63 | SMN1; SMN2 (0.64) | SMN1; SMN2HTTMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412355-A1 | NEW PYRAZOLO(3,4-D)PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | AstraZeneca AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002567-A1 | NEW PYRAZOLO[3,4-D]PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | WO | disclosed |