Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349933 | 0.87 | AR (0.39) | ARSLC22A12BCAT2BCAT1 | |
| SCHEMBL4911171 | 0.75 | HTR1A (0.46) | SMN1; SMN2ALDH1A1HPGDGAAPOLB | |
| SCHEMBL29530991 | 0.75 | HTR1A (0.46) | SMN1; SMN2ALDH1A1HPGDGAAPOLB | |
| SCHEMBL4739057 | 0.74 | AR (0.40) | ALDH1A1ARKDM4EKMT2A | |
| SCHEMBL5344230 | 0.73 | AR (0.45) | ARBCAT2BCAT1 | |
| SCHEMBL1804090 | 0.72 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1HPGDHTTGAA | |
| SCHEMBL5341131 | 0.71 | SLC22A12 (0.39) | SMN1; SMN2ALDH1A1HPGDHTTSLC22A12 | |
| SCHEMBL3581845 | 0.71 | CA1 (0.49) | SMN1; SMN2ALDH1A1HPGDHTTKDM4E | |
| SCHEMBL5346988 | 0.71 | SLC22A12 (0.41) | SMN1; SMN2ARSLC22A12KDM4ELMNA | |
| SCHEMBL14835744 | 0.70 | PIM1 (0.43) | SMN1; SMN2ALDH1A1HPGDHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434756-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003029185-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-04-10 | — | — | WO | disclosed |