Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 18/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316175 | 0.89 | EDNRB (0.81) | EDNRBMAPTEDNRA | |
| SCHEMBL6321599 | 0.87 | EDNRB (1.00) | EDNRB | |
| SCHEMBL8548530 | 0.80 | EDNRB (0.57) | EDNRBMAPTEDNRA | |
| SCHEMBL8550230 | 0.80 | EDNRB (0.66) | EDNRBMAPTEDNRA | |
| SCHEMBL8699090 | 0.79 | EDNRB (0.75) | EDNRB | |
| SCHEMBL8698304 | 0.79 | EDNRB (0.75) | EDNRB | |
| SCHEMBL8550887 | 0.79 | EDNRB (0.58) | EDNRBMAPTEDNRA | |
| SCHEMBL8551432 | 0.78 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8553797 | 0.78 | EDNRB (0.55) | EDNRBEDNRA | |
| SCHEMBL8553494 | 0.77 | EDNRB (0.52) | EDNRBMAPTEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441721-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GmbH (DE) | 2004-08-04 | — | — | EP | claimed |
| WO-2003039539-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GMBH (DE) | 2003-05-15 | — | — | WO | claimed |