SCHEMBL6657790

SCHEMBL6657790

CC1=Cc2ccc3ccccc3c2C1[Si](C)(C)C1C(C)=Cc2ccc3ccccc3c21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.37
KDM4E B2RXH2 2/20 0.37
TAAR1 Q96RJ0 1/20 0.37
CYP2C19 P33261 1/20 0.37
CYP2A6 P11509 4/20 0.37
TSHR P16473 3/20 0.37
ALDH1A1 P00352 3/20 0.37
HSD17B10 Q99714 2/20 0.37
TDP1 Q9NUW8 1/20 0.37
KMT2A Q03164 4/20 0.35
MEN1 O00255 3/20 0.35
MAPT P10636 2/20 0.35
HTT P42858 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
LMNA P02545 1/20 0.35
HSP90AA1 P07900 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MECP2 P51608 1/20 0.35
MBD2 Q9UBB5 1/20 0.35
HPRT1 P00492 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8664121 0.77 TAAR1 (0.35) CYP1A2KDM4ETAAR1CYP2C19TDP1
SCHEMBL8575892 0.77 ENPP3 (0.34) CYP1A2KDM4ECYP2C19CYP2A6TSHR
Hydrochloric Acid SCHEMBL5091217 0.77 CYP2A6 (0.38) CYP1A2KDM4ETAAR1CYP2C19CYP2A6
SCHEMBL27446697 0.77 CYP2A6 (0.42) CYP1A2KDM4ETAAR1CYP2C19CYP2A6
SCHEMBL5609098 0.76 TSHR (0.37) CYP1A2KDM4ETAAR1CYP2C19CYP2A6
SCHEMBL3061385 0.75 CYP2A6 (0.38) CYP1A2KDM4ECYP2A6TSHRALDH1A1
Hydrochloric Acid SCHEMBL28839426 0.75 CYP2A6 (0.36) CYP1A2KDM4ETAAR1CYP2C19CYP2A6
Hydrochloric Acid SCHEMBL5609376 0.75 CYP2A6 (0.36) CYP1A2KDM4ETAAR1CYP2C19CYP2A6
SCHEMBL8682597 0.73 CYP1A2 (0.39) CYP1A2KDM4ETAAR1CYP2C19CYP2A6
Hydrochloric Acid SCHEMBL5872697 0.72 CYP2A6 (0.34) CYP1A2KDM4ETAAR1CYP2C19CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0745606-B1 Process for the preparation of bridged metallocene complexes BASELL POLYOLEFINE GMBH (DE) 2004-07-28 EP disclosed
US-6620953-B1 Complexing dimethylbis(2-methyl-4,5-benzoindenyl)silane with transition metal compounds such as 2,4-di-tert-butylphenoxide, zirconium monochloride, to form polymerization catalysts BASSELL POLYOLEFINE GMBH (DE) 2003-09-16 US disclosed
EP-1133504-B1 METHOD FOR PRODUCING MONOARYLOXY-ANSA-METALLOCENES BASELL POLYOLEFINE GMBH (DE) 2003-03-12 EP disclosed
EP-0980375-A4 SILYLATED AND N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENT CO (US) 2003-01-22 EP disclosed
EP-1070072-A4 SILYLATED AND N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENT CO (US) 2002-09-25 EP disclosed
EP-1133504-A1 METHOD FOR PRODUCING MONOARYLOXY-ANSA-METALLOCENES Basell Polypropylen GmbH (DE) 2001-09-19 EP disclosed
EP-1070072-A1 SILYLATED AND N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENTIFIC COMPANY (US) 2001-01-24 EP disclosed
WO-2000047587-A1 SILYLATED AND N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENTIFIC COMPANY (US) 2000-08-17 WO disclosed
WO-2000031091-A1 METHOD FOR PRODUCING MONOARYLOXY-ANSA-METALLOCENES BASELL POLYPROPYLEN GMBH (DE) 2000-06-02 WO disclosed
EP-0980375-A1 N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENTIFIC COMPANY (US) 2000-02-23 EP disclosed
WO-1999038871-A1 SILYLATED AND N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENTIFIC COMPANY (US) 1999-08-05 WO disclosed
US-5831106-A POLYOLEFIN POLYMERIZATION CATALYST BASF AKTIENGESELLSCHAFT (DE) 1998-11-03 US disclosed
EP-0745606-A2 Process for the preparation of bridged metallocene complexes BASF AKTIENGESELLSCHAFT (DE) 1996-12-04 EP disclosed