SCHEMBL8575892

SCHEMBL8575892

CC1=Cc2cccc(-c3cccc4ccccc34)c2C1[Si](C)(C)C1c2ccccc2-c2ccccc21

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP3 O14638 1/20 0.34
ENPP1 P22413 1/20 0.34
ALOX15 P16050 4/20 0.33
MAPT P10636 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
DHFR P00374 1/20 0.33
KDM4E B2RXH2 5/20 0.32
ALDH1A1 P00352 4/20 0.32
HPGD P15428 3/20 0.32
MAPK1 P28482 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
TDP2 O95551 1/20 0.32
ALOX12 P18054 1/20 0.32
CASP3 P42574 1/20 0.32
HTT P42858 1/20 0.32
GALK1 P51570 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8574024 0.83 CHRNB2 (0.35)
SCHEMBL689942 0.79 DHFR (0.38) ENPP3ENPP1ALOX15MAPTSMN1; SMN2
SCHEMBL1453953 0.78 TDP1 (0.33) ENPP3ENPP1ALOX15MAPTSMN1; SMN2
SCHEMBL6657790 0.77 CYP1A2 (0.37) MAPTSMN1; SMN2RAB9AKDM4EALDH1A1
SCHEMBL1453940 0.77 GPR3 (0.33)
SCHEMBL3149399 0.77 ENPP3 (0.38) ENPP3ENPP1ALOX15MAPTSMN1; SMN2
SCHEMBL7618752 0.75 ALDH1A1 (0.37) ENPP3ENPP1ALOX15MAPTSMN1; SMN2
Hydrochloric Acid SCHEMBL5167145 0.75 ENPP3 (0.36) ENPP3ENPP1ALOX15MAPTSMN1; SMN2
SCHEMBL8574666 0.74 BCL2 (0.39) ALOX15MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL7783128 0.73 ENPP3 (0.32) ENPP3ENPP1ALOX15MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5770664-A Catalyst component for producing polyolefin, catalyst for producing polyolefin comprising the catalyst component, and process for producing polyolefin in the presence of the catalyst JAPAN POLYOLEFINS CO., LTD. (JP) 1998-06-23 US disclosed
EP-0707016-B1 Catalyst component for producing polyolefin, catalyst for producing polyolefin comprising the catalyst component, and process for producing polyolefin in the presence of the catalyst JAPAN POLYOLEFINS CO LTD (JP) 1997-09-24 EP disclosed
EP-0707016-A1 Catalyst component for producing polyolefin, catalyst for producing polyolefin comprising the catalyst component, and process for producing polyolefin in the presence of the catalyst JAPAN POLYOLEFINS CO., LTD. (JP) 1996-04-17 EP disclosed