Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6658081 | 1.00 | KDM4E (0.54) | KDM4EPOLBPKMALDH1A1FAAH | |
| Hydrochloric Acid SCHEMBL6663247 | 0.86 | NPBWR1 (0.55) | KDM4EPOLBALDH1A1HRH3L3MBTL1 | |
| SCHEMBL6659429 | 0.86 | L3MBTL1 (0.50) | L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6663643 | 0.86 | NPBWR1 (0.55) | KDM4EPOLBALDH1A1HRH3L3MBTL1 | |
| SCHEMBL6908168 | 0.86 | L3MBTL1 (0.50) | L3MBTL1 | |
| SCHEMBL6663904 | 0.86 | KMT2A (0.57) | KDM4EPOLBALDH1A1HRH3L3MBTL1 | |
| SCHEMBL6905958 | 0.86 | KMT2A (0.57) | KDM4EPOLBALDH1A1HRH3L3MBTL1 | |
| SCHEMBL27506526 | 0.84 | KDM4E (0.51) | KDM4EPOLBALDH1A1L3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6659280 | 0.83 | KDM4E (0.50) | KDM4EPOLBALDH1A1L3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6659274 | 0.83 | KDM4E (0.50) | KDM4EPOLBALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441728-A2 | MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY | Vertex Pharmaceuticals Incorporated (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037338-A2 | MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-05-08 | — | — | WO | disclosed |
| EP-1257544-A2 | PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE | Vertex Pharmaceuticals Incorporated (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001058891-A2 | PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-08-16 | — | — | WO | disclosed |