Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 9/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.44 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.44 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2623130 | 0.84 | TRPA1 (0.58) | TRPA1FLT3TTBK1TTBK2MRGPRX1 | |
| SCHEMBL1791375 | 0.82 | MERTK (0.55) | FLT3DRD1 | |
| SCHEMBL23069173 | 0.81 | TRPA1 (0.41) | TRPA1DRD1 | |
| SCHEMBL822148 | 0.81 | ALDH1A1 (0.47) | TRPA1FLT3TTBK1ALDH1A1KDM4E | |
| SCHEMBL1791378 | 0.78 | TRPA1 (0.40) | TRPA1FLT3CSF1R | |
| SCHEMBL5358444 | 0.78 | TRPA1 (0.35) | TRPA1 | |
| SCHEMBL7830504 | 0.75 | JAK2 (0.42) | TRPA1ALDH1A1KDM4EDRD1SMN1; SMN2 | |
| SCHEMBL2940695 | 0.72 | PDPK1 (0.36) | TRPA1 | |
| SCHEMBL14104450 | 0.72 | MAPT (0.44) | TRPA1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL23977400 | 0.71 | HAO1 (0.47) | TRPA1FLT3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444982-A1 | The use of purine derivatives as selective kinase inhibitors | MERCKLE GMBH (DE) | 2004-08-11 | — | — | EP | disclosed |