Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6659416 | 1.00 | OPRL1 (0.56) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL6659414 | 1.00 | OPRL1 (0.56) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL12539940 | 0.88 | OPRL1 (0.49) | OPRL1OPRM1OPRK1OPRD1MAOB | |
| SCHEMBL11815569 | 0.81 | OPRL1 (0.50) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL16536389 | 0.80 | MAOB (0.47) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL16536387 | 0.80 | MAOB (0.47) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL15335675 | 0.80 | MAOB (0.47) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL6665228 | 0.80 | OPRK1 (0.43) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL10060840 | 0.79 | OPRL1 (0.68) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL7815717 | 0.79 | OPRL1 (0.68) | OPRL1OPRM1OPRK1OPRD1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224954-A1 | Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds | GRUNENTHAL GMBH (DE) | 2004-11-11 | — | — | US | claimed |
| EP-1444212-A1 | SUBSTITUTED (1H)-QUINOXALIN-2-ONE COMPOUNDS AND SUBSTITUTED 4-ARYL- AND 4-HETEROARYLCYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2004-08-11 | — | — | EP | claimed |
| WO-2003037879-A1 | SUBSTITUTED (1H)-QUINOXALIN-2-ONE COMPOUNDS AND SUBSTITUTED 4-ARYL- AND 4-HETEROARYLCYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2003-05-08 | — | — | WO | claimed |
| US-20040224954-A1 | Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds | GRUNENTHAL GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| EP-1444212-A1 | SUBSTITUTED (1H)-QUINOXALIN-2-ONE COMPOUNDS AND SUBSTITUTED 4-ARYL- AND 4-HETEROARYLCYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003037879-A1 | SUBSTITUTED (1H)-QUINOXALIN-2-ONE COMPOUNDS AND SUBSTITUTED 4-ARYL- AND 4-HETEROARYLCYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224954-A1 | Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds | NQO2, NQO1, CYP2C8 | OPRL1 777/4885OPRM1 661/4885OPRK1 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.