Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.53 |
| ▸ | MMP9 | P14780 | 3/20 | 0.53 |
| ▸ | MMP8 | P22894 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783796 | 0.78 | SMN1; SMN2 (0.47) | NPC1RAB9AMAPTATMMEN1 | |
| SCHEMBL221808 | 0.75 | MMP2 (0.68) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL5349645 | 0.73 | MMP2 (0.47) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL220044 | 0.72 | MMP2 (0.68) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL25391210 | 0.71 | MMP2 (0.55) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL21777068 | 0.71 | MMP2 (0.62) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL31474762 | 0.70 | MMP2 (0.66) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL208169 | 0.70 | PARP1 (0.57) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL10943282 | 0.70 | RAB9A (0.83) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL2246922 | 0.70 | MMP2 (1.00) | MMP2MMP9MMP8MMP13NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390371-A1 | OXAZOLO-AND FUROPYRIMIDINES AND THEIR USE IN MEDICAMENTS AGAINST TUMORS | Novartis AG (CH) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002092603-A1 | OXAZOLO-AND FUROPYRIMIDINES AND THEIR USE IN MEDICAMENTS AGAINST TUMORS | NOVARTIS AG (CH) | 2002-11-21 | — | — | WO | disclosed |