Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272858 | 0.92 | TDP1 (0.36) | TDP1LMNACNR1ADRA1AKDM4E | |
| SCHEMBL30843185 | 0.88 | TDP1 (0.33) | TDP1LMNACNR1ADRA1AKDM4E | |
| Hydrochloric Acid SCHEMBL13859290 | 0.88 | ABCC3 (0.36) | TDP1LMNACNR1ADRA1AKDM4E | |
| Perchlorate SCHEMBL6661450 | 0.83 | LMNA (0.32) | TDP1LMNACNR1ADRA1AKDM4E | |
| SCHEMBL4745076 | 0.81 | LMNA (0.32) | TDP1LMNAKDM4E | |
| SCHEMBL4746164 | 0.81 | LMNA (0.32) | TDP1LMNAKDM4E | |
| SCHEMBL4745112 | 0.81 | LMNA (0.32) | TDP1LMNAKDM4E | |
| SCHEMBL17766693 | 0.81 | LMNA (0.32) | TDP1LMNAKDM4E | |
| SCHEMBL17766691 | 0.81 | LMNA (0.32) | TDP1LMNAKDM4E | |
| SCHEMBL2630682 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160267-B1 | CATALYST FOR OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, METHOD OF OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, AND POLY(OXYFLUOROPHENYLENE) DERIVATIVE | JAPAN SCIENCE & TECH CORP (JP) | 2004-08-04 | — | — | EP | disclosed |