Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.68 |
| ▸ | HTR2C | P28335 | 13/20 | 0.68 |
| ▸ | HTR2B | P41595 | 11/20 | 0.45 |
| ▸ | PNMT | P11086 | 4/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368756 | 0.81 | HTR2A (1.00) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL29051751 | 0.76 | HTR2A (0.59) | HTR2AHTR2C | |
| SCHEMBL6661043 | 0.74 | HTR2A (0.66) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL9058489 | 0.70 | HTR2A (0.62) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL29051650 | 0.70 | HTR2C (0.53) | HTR2AHTR2CHTR2BKDM1AADRA2A | |
| SCHEMBL5678916 | 0.69 | HTR2C (0.51) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL184089 | 0.66 | PNMT (0.61) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL9377934 | 0.66 | HTR2C (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL6298572 | 0.66 | HTR2A (0.73) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL3757689 | 0.65 | HTR2A (0.71) | HTR2AHTR2CHTR2BPNMTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |