Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.66 |
| ▸ | HTR2C | P28335 | 5/20 | 0.66 |
| ▸ | PNMT | P11086 | 1/20 | 0.51 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 4/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25591142 | 0.82 | PNMT (0.46) | HTR2AHTR2CPNMTASIC3HTR2B | |
| Hydrochloric Acid SCHEMBL30098020 | 0.81 | PNMT (0.44) | HTR2AHTR2CPNMTASIC3HTR2B | |
| SCHEMBL2368756 | 0.79 | HTR2A (1.00) | HTR2AHTR2CPNMTASIC3HTR2B | |
| SCHEMBL9058489 | 0.77 | HTR2A (0.62) | HTR2AHTR2CPNMTHTR2BKDM1A | |
| SCHEMBL1706762 | 0.76 | KDM1A (0.53) | HTR2AHTR2CPNMTASIC3HTR2B | |
| SCHEMBL29804270 | 0.76 | KDM1A (0.53) | HTR2AHTR2CPNMTASIC3HTR2B | |
| SCHEMBL6660144 | 0.74 | HTR2A (0.68) | HTR2AHTR2CPNMTHTR2BKDM1A | |
| SCHEMBL7680539 | 0.74 | PNMT (0.49) | HTR2AHTR2CPNMTASIC3HTR2B | |
| SCHEMBL2481940 | 0.73 | PNMT (0.42) | HTR2AHTR2CPNMTASIC3HTR2B | |
| SCHEMBL2343653 | 0.73 | GAA (0.39) | HTR2AHTR2CCMA1AHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |