Sugi Predict

Sugi Predict / Compounds / SCHEMBL6660786

SCHEMBL6660786

SCHEMBL6660786

C[C@@H](O)CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ SMYD2 Q9NRG4 3/20 0.40
▸ CYP3A4 P08684 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ LMNA P02545 1/20 0.36
▸ RIPK1 Q13546 2/20 0.34
▸ TRPA1 O75762 1/20 0.33
▸ SLC6A2 P23975 2/20 0.32
▸ SLC6A4 P31645 2/20 0.32
▸ SLC6A3 Q01959 2/20 0.32
▸ KCNH3 Q9ULD8 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.30
▸ CYP1A2 P05177 1/20 0.30
▸ CYP2D6 P10635 1/20 0.30
▸ TSHR P16473 1/20 0.30
▸ AOC3 Q16853 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10004139 1.00 SMYD2 (0.40) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL224828 1.00 SMYD2 (0.40) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL28946558 0.91 SMYD2 (0.41) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL28946557 0.91 SMYD2 (0.41) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL4815429 0.91 SMYD2 (0.41) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL13866319 0.89 SMYD2 (0.40) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL9295566 0.89 SMYD2 (0.40) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL4402734 0.89 SMYD2 (0.41) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL18641636 0.88 SMYD2 (0.40) SMYD2CYP3A4HTTSMN1; SMN2LMNA
SCHEMBL31644855 0.88 SMYD2 (0.38) SMYD2CYP3A4HTTSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240246992-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS SERVIER LAB (FR) 2024-07-25 — — US disclosed
EP-4308570-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS Les Laboratoires Servier (FR) 2024-01-24 — — EP disclosed
CN-117425661-A Macrocyclic LRRK2 kinase inhibitors 法国施维雅药厂 2024-01-19 — — CN disclosed
WO-2023119098-A1 PROTEIN KINASE C THETA INHIBITORS Galderma Holding SA (CH) 2023-06-29 — — WO disclosed
WO-2022224223-A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CORONAVIRAL RELATED DISEASES NOVARTIS AG (CH) 2022-10-27 — — WO disclosed
WO-2022194976-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS LES LABORATOIRES SERVIER (FR) 2022-09-22 — — WO disclosed
EP-1012142-B1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2004-08-11 — — EP disclosed
US-6046217-A TREATING AN INFLAMMATORY DISEASE SUSCEPTIBLE TO TREATMENT WITH A NON-STEROIDAL ANTI-INFLAMMATORY AGENT COMPRISING ADMINISTERING TO A PATIENT IN NEED OF SUCH TREATMENT A NONTOXIC 3-PHENYL SUBSTITUTED PYRIDINES MERCK FROSST CANADA & CO. (CA) 2000-04-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240246992-A1 MACROCYCLIC LRRK2 KINASE INHIBITORS LRRK2, PARK7, PINK1 SMYD2 3926/4885CYP3A4 4680/4885HTT 884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.