Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 6/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851272 | 0.86 | GLS (0.55) | GLSKDM4ABRD4CREBBPAKT1 | |
| SCHEMBL30192965 | 0.86 | GLS (0.55) | GLSKDM4ABRD4CREBBPAKT1 | |
| SCHEMBL23775214 | 0.85 | LSS (0.52) | KDM4AAKT1NAMPTCA12CA1 | |
| SCHEMBL30069429 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPBRD9 | |
| SCHEMBL13981921 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPBRD9 | |
| SCHEMBL1165088 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPBRD9 | |
| SCHEMBL8342682 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPBRD9 | |
| SCHEMBL16181822 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPBRD9 | |
| SCHEMBL3507603 | 0.83 | GLS (0.49) | GLSKDM4ABRD4CREBBPBRD9 | |
| SCHEMBL5102152 | 0.83 | GLS (0.54) | GLSKDM4ABRD4CREBBPBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435933-A1 | 5'-CARBAMOYL-2'-METHYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032970-A1 | 5'-CARBAMOYL-2'-METHYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |