Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.72 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.72 |
| ▸ | CCR1 | P32246 | 5/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | HRH2 | P25021 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6665371 | 0.84 | OPRM1 (0.72) | OPRM1OPRL1CCR1ADRA2ADRD4 | |
| SCHEMBL6663581 | 0.83 | OPRM1 (0.59) | OPRM1OPRL1CCR1ADRA2ADRD4 | |
| SCHEMBL6661585 | 0.82 | OPRM1 (0.58) | OPRM1OPRL1CCR1ADRA2ADRD4 | |
| SCHEMBL6662792 | 0.82 | OPRM1 (0.55) | OPRM1OPRL1CCR1ADRA2ADRD4 | |
| SCHEMBL6841843 | 0.82 | OPRM1 (0.55) | OPRM1OPRL1CCR1ADRA2ADRD4 | |
| SCHEMBL6662830 | 0.75 | OPRM1 (0.57) | OPRM1OPRL1CCR1ADRA2ADRD4 | |
| Water SCHEMBL7738863 | 0.74 | OPRM1 (0.67) | OPRM1OPRL1ADRA2ADRD4SLC6A4 | |
| SCHEMBL6661392 | 0.74 | KCNA3 (0.77) | CCR1RAB9ANPSR1KCNA3CCR3 | |
| SCHEMBL6662217 | 0.74 | OPRM1 (0.53) | OPRM1OPRL1CCR1ADRA2ADRD4 | |
| SCHEMBL5092029 | 0.74 | SLC6A9 (0.60) | OPRM1OPRL1ADRA2ADRD4SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097924-B1 | 4-hydroxy-4-phenylpiperidine derivatives having opioid agonist activity and pharmaceuticals containing the same | SSP CO LTD (JP) | 2004-08-25 | — | — | EP | disclosed |
| US-6362203-B1 | ANALGESICS | SSP CO., LTD (JP) | 2002-03-26 | — | — | US | disclosed |
| EP-1097924-A1 | 4-hydroxy-4-phenylpiperidine derivatives having -opioid agonist activity and pharmaceuticals containing the same | SSP Co., Ltd. (JP) | 2001-05-09 | — | — | EP | disclosed |