SCHEMBL6661654

SCHEMBL6661654

CC(N)CCC(N)c1ccnc2cc(Cl)ccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 3/20 0.50
SOS2 Q07890 1/20 0.50
CYP1A2 P05177 1/20 0.46
FERMT2 Q96AC1 3/20 0.45
POLB P06746 1/20 0.44
THRB P10828 1/20 0.44
TDP1 Q9NUW8 2/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
PRNP P04156 1/20 0.44
APP P05067 1/20 0.44
CHRM2 P08172 1/20 0.44
CHRM4 P08173 1/20 0.44
CHRM5 P08912 1/20 0.44
ADRA2A P08913 1/20 0.44
CHRM1 P11229 1/20 0.44
NQO2 P16083 1/20 0.44
ADRA2B P18089 1/20 0.44
ADRA2C P18825 1/20 0.44
CHRM3 P20309 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29625389 1.00 NR4A2 (0.50) NR4A2SOS2CYP1A2FERMT2POLB
SCHEMBL4365534 0.87 FERMT2 (0.55) NR4A2SOS2CYP1A2FERMT2TDP1
SCHEMBL8539820 0.84 NR4A2 (0.47) NR4A2SOS2CYP1A2FERMT2POLB
SCHEMBL16568037 0.83 NR4A2 (0.46) NR4A2SOS2CYP1A2FERMT2POLB
SCHEMBL902310 0.83 FERMT2 (0.56) NR4A2SOS2CYP1A2FERMT2TDP1
SCHEMBL5275609 0.82 NR4A2 (0.56) NR4A2SOS2CYP1A2FERMT2POLB
SCHEMBL4367045 0.82 FERMT2 (0.56) NR4A2SOS2CYP1A2FERMT2TDP1
SCHEMBL4374933 0.81 NR4A2 (0.46) NR4A2SOS2CYP1A2FERMT2POLB
SCHEMBL27466148 0.81 NR4A2 (0.54) NR4A2SOS2CYP1A2FERMT2TDP1
SCHEMBL24420728 0.80 NR4A2 (0.58) NR4A2SOS2CYP1A2FERMT2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114560847-B Chloroquine photoaffinity molecular probe and preparation method and application thereof 中国中医科学院中药研究所 2022-07-29 CN claimed
CN-114560847-A Chloroquine photoaffinity molecular probe and preparation method and application thereof 中国中医科学院中药研究所 2022-05-31 CN claimed
CN-113440528-A Application of optically pure 4-aminoquinoline compound in preparation of drugs for treating coronavirus 上海华理生物医药股份有限公司 2021-09-28 CN claimed
EP-0946744-B1 NOVEL POLYMERIC COMPLEXES FOR THE TRANSFECTION OF NUCLEIC ACIDS, WITH RESIDUES CAUSING THE DESTABILISATION OF CELL MEMBRANES IDM IMMUNO DESIGNED MOLECULES (FR) 2004-08-18 EP claimed
EP-1135481-B1 NEW OLIGOMERIC CONJUGATES LIABLE TO TRANSFER BIOLOGICAL MOLECULES INTO CELLS IDM IMMUNO DESIGNED MOLECULES (FR) 2004-02-25 EP claimed
US-6372499-B1 TRANSFECTION EFFICIENCY I.D.M. IMMUNO-DESIGNED MOLECULES (FR) 2002-04-16 US claimed
CN-114560847-B Chloroquine photoaffinity molecular probe and preparation method and application thereof 中国中医科学院中药研究所 2022-07-29 CN disclosed
CN-114560847-A Chloroquine photoaffinity molecular probe and preparation method and application thereof 中国中医科学院中药研究所 2022-05-31 CN disclosed
EP-0946744-B1 NOVEL POLYMERIC COMPLEXES FOR THE TRANSFECTION OF NUCLEIC ACIDS, WITH RESIDUES CAUSING THE DESTABILISATION OF CELL MEMBRANES IDM IMMUNO DESIGNED MOLECULES (FR) 2004-08-18 EP disclosed
EP-1135481-B1 NEW OLIGOMERIC CONJUGATES LIABLE TO TRANSFER BIOLOGICAL MOLECULES INTO CELLS IDM IMMUNO DESIGNED MOLECULES (FR) 2004-02-25 EP disclosed
US-6372499-B1 TRANSFECTION EFFICIENCY I.D.M. IMMUNO-DESIGNED MOLECULES (FR) 2002-04-16 US disclosed
EP-1135481-A1 NEW OLIGOMERIC CONJUGATES LIABLE TO TRANSFER BIOLOGICAL MOLECULES INTO CELLS I.D.M. IMMUNO-DESIGNED MOLECULES (FR) 2001-09-26 EP disclosed
WO-2000032764-A1 NEW OLIGOMERIC CONJUGATES LIABLE TO TRANSFER BIOLOGICAL MOLECULES INTO CELLS I.D.M. IMMUNO-DESIGNED MOLECULES (FR) 2000-06-08 WO disclosed
EP-0946744-A1 NOVEL POLYMERIC COMPLEXES FOR THE TRANSFECTION OF NUCLEIC ACIDS, WITH RESIDUES CAUSING THE DESTABILISATION OF CELL MEMBRANES I.D.M. IMMUNO-DESIGNED MOLECULES (FR) 1999-10-06 EP disclosed
WO-1998022610-A1 NOVEL POLYMERIC COMPLEXES FOR THE TRANSFECTION OF NUCLEIC ACIDS, WITH RESIDUES CAUSING THE DESTABILISATION OF CELL MEMBRANES I.D.M. IMMUNO-DESIGNED MOLECULES (FR) 1998-05-28 WO disclosed