Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.66 |
| ▸ | EDNRA | P25101 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546805 | 0.92 | EDNRB (0.61) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL8592785 | 0.91 | EDNRB (0.69) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL6661772 | 0.91 | EDNRB (0.79) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8550347 | 0.89 | EDNRB (0.66) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL8550818 | 0.89 | EDNRB (0.83) | EDNRBEDNRA | |
| SCHEMBL8551602 | 0.88 | EDNRB (0.69) | EDNRBEDNRAKDM4EHSD17B10PLA2G2A | |
| SCHEMBL8549097 | 0.86 | EDNRB (0.67) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8553472 | 0.85 | EDNRB (0.81) | EDNRBEDNRA | |
| SCHEMBL8550751 | 0.85 | EDNRB (0.46) | EDNRBEDNRAKDM4EHSD17B10PLA2G2A | |
| SCHEMBL8548888 | 0.85 | EDNRB (0.65) | EDNRBEDNRAPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |