Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 17/20 | 0.42 |
| ▸ | MMP9 | P14780 | 11/20 | 0.41 |
| ▸ | MMP13 | P45452 | 11/20 | 0.41 |
| ▸ | MMP1 | P03956 | 8/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940232 | 0.74 | ADAM17 (0.72) | ADAM17MMP9MMP13MMP1MMP7 | |
| SCHEMBL6706950 | 0.73 | ADAM17 (0.51) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL3939495 | 0.67 | ADAM17 (0.72) | ADAM17MMP9MMP13MMP1MMP7 | |
| SCHEMBL3939279 | 0.67 | ADAM17 (0.46) | ADAM17MMP9MMP13MMP1MMP7 | |
| SCHEMBL6656982 | 0.66 | ADAM17 (0.54) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL7412498 | 0.65 | PSMB5 (0.43) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL3940241 | 0.63 | ADAM17 (0.73) | ADAM17MMP9MMP13MMP1MMP7 | |
| SCHEMBL3942564 | 0.62 | ADAM17 (0.77) | ADAM17MMP9MMP13MMP1MMP7 | |
| SCHEMBL6656323 | 0.62 | ADAM17 (0.46) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6270069 | 0.62 | ADAM17 (0.51) | ADAM17MMP9MMP13MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | claimed |