Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | EGFR | P00533 | 11/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | STK10 | O94804 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | JAK3 | P52333 | 1/20 | 0.65 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.65 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.65 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.65 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.65 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5473733 | 0.85 | KDR (0.74) | KDREGFRGAKRIPK2STK10 | |
| SCHEMBL28726464 | 0.84 | KDR (0.76) | KDREGFRGAKRIPK2STK10 | |
| SCHEMBL5569469 | 0.84 | KDR (0.72) | KDREGFRGAKRIPK2STK10 | |
| Hydrochloric Acid SCHEMBL5477767 | 0.84 | EGFR (0.73) | KDREGFRGAKRIPK2STK10 | |
| SCHEMBL25682990 | 0.82 | KDR (0.78) | KDREGFRGAKRIPK2STK10 | |
| SCHEMBL6162829 | 0.82 | KDR (0.70) | KDREGFR | |
| SCHEMBL6162952 | 0.82 | KDR (0.70) | KDREGFR | |
| SCHEMBL18158156 | 0.82 | AURKB (0.80) | KDREGFRGAKRIPK2STK10 | |
| Hydrochloric Acid SCHEMBL8809205 | 0.81 | AURKB (0.78) | KDREGFRGAKRIPK2STK10 | |
| SCHEMBL5473778 | 0.81 | EGFR (0.80) | KDREGFRGAKRIPK2STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |