Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TACR2 | P21452 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661492 | 0.90 | KMT2A (0.45) | KMT2ASLC6A2SLC6A4OPRK1TACR2 | |
| SCHEMBL6949126 | 0.90 | KMT2A (0.46) | KMT2ASLC6A2SLC6A4OPRK1TACR2 | |
| SCHEMBL6948569 | 0.88 | KMT2A (0.43) | KMT2ASLC6A2SLC6A4OPRK1TACR2 | |
| SCHEMBL6667597 | 0.87 | KMT2A (0.46) | KMT2ASLC6A2SLC6A4TACR2TACR1 | |
| SCHEMBL6952753 | 0.87 | KMT2A (0.43) | KMT2ASLC6A2SLC6A4OPRK1TACR1 | |
| SCHEMBL14028100 | 0.85 | SLC6A4 (0.42) | KMT2ASLC6A2SLC6A4 | |
| SCHEMBL4941176 | 0.84 | KDM4E (0.43) | KMT2ASLC6A2SLC6A4TACR2 | |
| SCHEMBL4940368 | 0.83 | KMT2A (0.40) | KMT2ASLC6A2SLC6A4TACR2TACR1 | |
| SCHEMBL5199616 | 0.80 | CCR5 (0.42) | SLC6A2SLC6A4TACR2TACR1 | |
| SCHEMBL6667215 | 0.79 | TACR2 (0.38) | KMT2ATACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165528-B1 | NOVEL MORPHOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SANOFI SYNTHELABO (FR) | 2004-09-01 | — | — | EP | disclosed |
| US-6506750-B1 | N-(phenylacetyl)morpholine derivatives useful as NK1 receptor antagonists, a process for the preparation thereof, and pharmaceutical compositions containing them as active principle. | SANOFI-SYNTHELABO (FR) | 2003-01-14 | — | — | US | disclosed |