SCHEMBL6663174

SCHEMBL6663174

O=C(Nn1cncn1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
GAA P10253 2/20 0.53
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
HTT P42858 1/20 0.45
BCAT2 O15382 1/20 0.45
HDAC1 Q13547 3/20 0.42
HDAC6 Q9UBN7 3/20 0.42
HDAC3 O15379 1/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
IDO1 P14902 1/20 0.42
ALOX15 P16050 1/20 0.42
CA9 Q16790 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HSD17B10 Q99714 1/20 0.42
HDAC8 Q9BY41 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9821305 0.83 CYP2D6 (0.45) ALDH1A1HDAC1HDAC6
SCHEMBL9713098 0.75 CYP3A4 (0.49) GAACYP3A4CYP2C9CYP2C19HTT
SCHEMBL5924206 0.74 HDAC6 (0.35) ALDH1A1GAACYP3A4CYP2C9CYP2C19
SCHEMBL3668615 0.72 SMN1; SMN2 (0.52) ALDH1A1GAACYP3A4CYP2C9CYP2C19
SCHEMBL12841358 0.71 TSHR (0.70) ALDH1A1GAACYP3A4CYP2C9CYP2C19
SCHEMBL17714580 0.71 CYP3A4 (0.52) GAACYP3A4CYP2C9CYP2C19HTT
SCHEMBL29531015 0.70 NAMPT (0.54) GAASMN1; SMN2HDAC1HDAC6LMNA
SCHEMBL1608161 0.69 ALDH1A1 (0.61) ALDH1A1GAASMN1; SMN2LMNA
SCHEMBL6598806 0.69 TSHR (0.53) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL7982337 0.68 CYP26A1 (0.44) ALDH1A1GAACYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1322309-A4 HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS NEUROGEN CORP (US) 2004-10-13 EP disclosed
EP-1322309-A2 HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS Neurogen Corporation (US) 2003-07-02 EP disclosed
WO-2002049993-A2 HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS NEUROGEN CORPORATION (US) 2002-06-27 WO disclosed