Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9204287 | 0.87 | INSR (0.44) | SMN1; SMN2NPSR1PTPN1MAPTKMT2A | |
| SCHEMBL13652086 | 0.85 | INSR (0.45) | SMN1; SMN2NPSR1MAPTKMT2APOLB | |
| SCHEMBL11516326 | 0.79 | MAPT (0.45) | SMN1; SMN2NPSR1PTPN1MAPTKMT2A | |
| Iodide SCHEMBL7335651 | 0.77 | MAPT (0.47) | SMN1; SMN2NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL12301906 | 0.75 | PIK3CA (0.37) | SMN1; SMN2MAPTKMT2AMEN1POLB | |
| SCHEMBL4822992 | 0.74 | MAPT (0.48) | SMN1; SMN2NPSR1MAPTPOLBINSR | |
| SCHEMBL12301903 | 0.73 | ESR1 (0.39) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL13838250 | 0.71 | APP (0.33) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL12301904 | 0.69 | APP (0.47) | APP | |
| SCHEMBL12301900 | 0.69 | AR (0.36) | MAPTKMT2AMEN1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004010761-A2 | PESTICIDAL CYANINE DYE DERIVATIVES | FMC CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |