Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ARG2 | P78540 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664094 | 0.98 | MAPK1 (0.62) | MAPK1MAOBL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL15684281 | 0.81 | SIGMAR1 (0.52) | L3MBTL1NPC1SMN1; SMN2RAB9AHPGD | |
| SCHEMBL1616064 | 0.81 | MAPK1 (0.57) | MAPK1MAOBTSHRSIGMAR1ALDH1A1 | |
| SCHEMBL1616428 | 0.81 | MAPK1 (0.57) | MAPK1MAOBL3MBTL1SIGMAR1MAPT | |
| SCHEMBL1616066 | 0.81 | MAPK1 (0.57) | MAPK1MAOBTSHRSIGMAR1ALDH1A1 | |
| SCHEMBL6666145 | 0.81 | MAPK1 (0.57) | MAPK1MAOBL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL1616429 | 0.81 | MAPK1 (0.57) | MAPK1MAOBL3MBTL1SIGMAR1MAPT | |
| SCHEMBL12230208 | 0.80 | MAPK1 (0.52) | MAPK1L3MBTL1TSHRMAPTALDH1A1 | |
| SCHEMBL949223 | 0.79 | TSHR (0.48) | MAPK1MAOBL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL945418 | 0.77 | MAOB (0.48) | MAPK1MAOBL3MBTL1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499558-B | Asymmetric reduction method of chiral spiro-bis-boron catalytic substituted pyridine and application thereof | 南开大学 | 2022-10-18 | — | — | CN | disclosed |
| CN-111499558-A | Asymmetric reduction method for chiral spiro-bisboron catalyzed substituted pyridine and application thereof | 南开大学 | 2020-08-07 | — | — | CN | disclosed |
| WO-2004024684-A2 | ENANTIOSELECTIVE AMINATION AND ETHERIFICATION | YALE UNIVERSITY (US) | 2004-03-25 | — | — | WO | disclosed |
| US-4652572-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-03-24 | — | — | US | disclosed |
| US-4547512-A | HISTAMINE H2-ANTAGONIST | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-15 | — | — | US | disclosed |
| EP-0065825-B1 | PYRIDINE DERIVATIVES AS HISTAMINE H2 ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-19 | — | — | EP | disclosed |
| US-4439437-A | 2-[2-Thiazolyl or 2-guanidino-4-thiazolyl methylthioethyl(or butyl)amino]-3-(hydroxy or carboxy)pyridines, compositions containing same and method of use | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-03-27 | — | — | US | disclosed |
| EP-0065825-A1 | Pyridine derivatives as histamine H2 antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-12-01 | — | — | EP | disclosed |