Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | WNT3 | P56703 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD5 | P21918 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521718 | 0.87 | MCHR1 (0.48) | MEN1KMT2ACACNA1FDRD4DRD5 | |
| SCHEMBL6904670 | 0.85 | DPP8 (0.49) | CACNA1BCACNA1CFAAHLMNA | |
| SCHEMBL6664501 | 0.77 | CNR1 (0.41) | WNT3SFRP1HTR2ALMNAHTR2C | |
| SCHEMBL6664724 | 0.74 | DPP8 (0.49) | CACNA1BCACNA1CFAAHLMNAPTGER4 | |
| SCHEMBL6662353 | 0.73 | DPP8 (0.50) | CACNA1BCACNA1CFAAHLMNA | |
| SCHEMBL6902204 | 0.73 | DPP8 (0.50) | CACNA1BCACNA1CFAAHLMNA | |
| SCHEMBL6902200 | 0.73 | DPP8 (0.50) | CACNA1BCACNA1CFAAHLMNA | |
| SCHEMBL6659166 | 0.72 | DPP8 (0.49) | MEN1KMT2ACACNA1BCACNA1CLMNA | |
| SCHEMBL6663014 | 0.72 | MAPT (0.54) | MEN1KMT2ACACNA1BCACNA1CTSHR | |
| SCHEMBL6908549 | 0.72 | MAPT (0.54) | MEN1KMT2ACACNA1BCACNA1CTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441728-A2 | MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY | Vertex Pharmaceuticals Incorporated (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037338-A2 | MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-05-08 | — | — | WO | disclosed |