Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | WNT3 | P56703 | 1/20 | 0.41 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521716 | 0.87 | ALDH1A1 (0.50) | WNT3SFRP1MCHR1NPBWR1KDM4E | |
| SCHEMBL6904670 | 0.78 | DPP8 (0.49) | CNR1CNR2LMNAMAPTALDH1A1 | |
| SCHEMBL6664503 | 0.77 | MEN1 (0.42) | WNT3SFRP1LMNAMCHR1NPBWR1 | |
| Hydrochloric Acid SCHEMBL6655911 | 0.70 | KMT2A (0.50) | KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6906622 | 0.70 | KMT2A (0.50) | KDM4EALDH1A1 | |
| SCHEMBL6663657 | 0.69 | HSD11B1 (0.55) | LMNAKDM4EALDH1A1 | |
| SCHEMBL6908168 | 0.69 | L3MBTL1 (0.50) | — | |
| SCHEMBL6663653 | 0.69 | HSD11B1 (0.55) | LMNAKDM4EALDH1A1 | |
| SCHEMBL6659429 | 0.69 | L3MBTL1 (0.50) | — | |
| SCHEMBL6902204 | 0.68 | DPP8 (0.50) | CNR1CNR2LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441728-A2 | MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY | Vertex Pharmaceuticals Incorporated (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037338-A2 | MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-05-08 | — | — | WO | disclosed |