Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410861 | 1.00 | TACR1 (0.38) | TACR1HSD17B10EDNRBEDNRAMEN1 | |
| SCHEMBL6410860 | 1.00 | TACR1 (0.38) | TACR1HSD17B10EDNRBEDNRAMEN1 | |
| SCHEMBL6418985 | 0.84 | TACR1 (0.44) | TACR1MEN1KMT2AATMALDH1A1 | |
| SCHEMBL671559 | 0.82 | HSD17B10 (0.45) | HSD17B10EDNRBEDNRATNKS2FFAR1 | |
| SCHEMBL671560 | 0.82 | HSD17B10 (0.45) | HSD17B10EDNRBEDNRATNKS2FFAR1 | |
| SCHEMBL671561 | 0.82 | HSD17B10 (0.45) | HSD17B10EDNRBEDNRATNKS2FFAR1 | |
| SCHEMBL6411515 | 0.81 | TSHR (0.40) | TACR1 | |
| SCHEMBL6414378 | 0.81 | CYP2C19 (0.41) | TACR1HSD17B10 | |
| SCHEMBL6417317 | 0.79 | MAPT (0.47) | TACR1MEN1KMT2AALDH1A1 | |
| SCHEMBL6415621 | 0.78 | P2RX7 (0.39) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004004727-A1 | 3,4-DIHYDROISOQUINOLIN-1-ONE DERIVATIVES AS INDUCERS OF APOPTOSIS | AXYS PHARMACEUTICALS, INC. (US) | 2004-01-15 | — | — | WO | disclosed |