Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL671561 | 1.00 | HSD17B10 (0.45) | HSD17B10TNKS2PARP3ALDH1A1CYP1A2 | |
| SCHEMBL671560 | 1.00 | HSD17B10 (0.45) | HSD17B10TNKS2PARP3ALDH1A1CYP1A2 | |
| Isophthalic Acid SCHEMBL27999411 | 0.89 | KMT2A (0.42) | HSD17B10PARP3ALDH1A1FFAR1 | |
| SCHEMBL6410860 | 0.82 | TACR1 (0.38) | HSD17B10TNKS2ALDH1A1EDNRAEDNRB | |
| SCHEMBL6410861 | 0.82 | TACR1 (0.38) | HSD17B10TNKS2ALDH1A1EDNRAEDNRB | |
| SCHEMBL6664525 | 0.82 | TACR1 (0.38) | HSD17B10TNKS2ALDH1A1EDNRAEDNRB | |
| SCHEMBL9204212 | 0.77 | TNKS2 (0.46) | HSD17B10TNKS2PARP3ALDH1A1CYP1A2 | |
| SCHEMBL9204202 | 0.77 | TNKS2 (0.46) | HSD17B10TNKS2PARP3ALDH1A1CYP1A2 | |
| SCHEMBL9204206 | 0.77 | TNKS2 (0.46) | HSD17B10TNKS2PARP3ALDH1A1CYP1A2 | |
| SCHEMBL6416249 | 0.76 | KDM4E (0.51) | ALDH1A1CYP1A2HTTMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073920-B2 | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor | PURDUE RESEARCH FOUNDATION (US) | 2015-07-07 | — | — | US | disclosed |
| US-20130143878-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | PURDUE RESEARCH FOUNDATION (US) | 2013-06-06 | — | — | US | disclosed |
| WO-2012024437-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | PURDUE RESEARCH FOUNDATION (US) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143878-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | KRAS, QDPR, BTD | HSD17B10 3124/4885TNKS2 364/4885PARP3 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.