SCHEMBL6664575

SCHEMBL6664575

O=C1CCC(c2ccc(F)c(F)c2)(C2CCCCC2)CC1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 6/20 0.52
SLC6A3 Q01959 6/20 0.52
SLC6A2 P23975 5/20 0.52
PDE4A P27815 6/20 0.38
PDE4B Q07343 6/20 0.38
PDE4C Q08493 6/20 0.38
PDE4D Q08499 6/20 0.38
DDB1 Q16531 1/20 0.37
CRBN Q96SW2 1/20 0.37
CYP19A1 P11511 2/20 0.35
TBXAS1 P24557 1/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP3A4 P08684 1/20 0.34
CHRM5 P08912 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6664581 0.88 SLC6A3 (0.52) SLC6A4SLC6A3SLC6A2PDE4APDE4B
SCHEMBL28624808 0.86 SLC6A4 (0.67) SLC6A4SLC6A3SLC6A2CYP3A4
Ethylene SCHEMBL28629416 0.83 SLC6A4 (0.63) SLC6A4SLC6A3SLC6A2CYP3A4
SCHEMBL6689139 0.77 SLC6A4 (0.50) SLC6A4SLC6A3SLC6A2NPC1RAB9A
SCHEMBL28351516 0.77 SLC6A2 (0.41) SLC6A4SLC6A3SLC6A2PDE4APDE4B
SCHEMBL29097452 0.76 SLC6A4 (0.55) SLC6A4SLC6A3SLC6A2CYP3A4
SCHEMBL6524968 0.75 SLC6A4 (0.51) SLC6A4SLC6A3SLC6A2CYP3A4
SCHEMBL8921676 0.73 SLC6A4 (0.49) SLC6A4SLC6A3SLC6A2CYP3A4
SCHEMBL8921688 0.73 SLC6A4 (0.49) SLC6A4SLC6A3SLC6A2CYP3A4
SCHEMBL8921677 0.73 SLC6A4 (0.49) SLC6A4SLC6A3SLC6A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1012148-B1 MONOACETALS OF BICYCLOHEXYL-4,4-DIONE AND THEIR USE IN PREPARING LIQUID CRYSTALS ROLIC AG (CH) 2004-09-15 EP disclosed
EP-1012148-A1 MONOACETALS OF BICYCLOHEXYL-4,4-DIONE AND THEIR USE IN PREPARING LIQUID CRYSTALS Rolic AG (CH) 2000-06-28 EP disclosed
WO-1999012920-A1 MONOACETALS OF BICYCLOHEXYL-4,4-DIONE AND THEIR USE IN PREPARING LIQUID CRYSTALS ROLIC AG (CH) 1999-03-18 WO disclosed