SCHEMBL6664581

SCHEMBL6664581

O=C1CCC(C2(c3ccc(F)c(F)c3)CCCCC2)CC1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 15/20 0.52
SLC6A4 P31645 14/20 0.52
SLC6A2 P23975 10/20 0.52
DDB1 Q16531 1/20 0.37
CRBN Q96SW2 1/20 0.37
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
CYP3A4 P08684 4/20 0.33
CYP2D6 P10635 4/20 0.33
KCNH2 Q12809 4/20 0.33
CYP1A1 P04798 3/20 0.33
CYP1A2 P05177 3/20 0.33
ABCC9 O60706 1/20 0.32
ABCC8 Q09428 1/20 0.32
KCNJ11 Q14654 1/20 0.32
KCNJ8 Q15842 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6664575 0.88 SLC6A4 (0.52) SLC6A3SLC6A4SLC6A2DDB1CRBN
SCHEMBL28624808 0.86 SLC6A4 (0.67) SLC6A3SLC6A4SLC6A2CYP3A4CYP2D6
Ethylene SCHEMBL28629416 0.83 SLC6A4 (0.63) SLC6A3SLC6A4SLC6A2CYP3A4CYP2D6
SCHEMBL7760357 0.77 SLC6A3 (0.53) SLC6A3SLC6A4SLC6A2CYP2D6KCNH2
SCHEMBL6689140 0.77 SLC6A3 (0.50) SLC6A3SLC6A4SLC6A2CYP3A4CYP2D6
SCHEMBL29097452 0.76 SLC6A4 (0.55) SLC6A3SLC6A4SLC6A2CYP3A4CYP2D6
SCHEMBL6524970 0.75 SLC6A4 (0.51) SLC6A3SLC6A4SLC6A2CYP2D6KCNH2
SCHEMBL8921684 0.74 SLC6A3 (0.50) SLC6A3SLC6A4SLC6A2CYP2D6KCNH2
SCHEMBL9180327 0.73 SLC6A3 (0.49) SLC6A3SLC6A4SLC6A2CYP3A4CYP2D6
SCHEMBL8536568 0.72 SLC6A4 (0.48) SLC6A3SLC6A4SLC6A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1012148-B1 MONOACETALS OF BICYCLOHEXYL-4,4-DIONE AND THEIR USE IN PREPARING LIQUID CRYSTALS ROLIC AG (CH) 2004-09-15 EP disclosed
EP-1012148-A1 MONOACETALS OF BICYCLOHEXYL-4,4-DIONE AND THEIR USE IN PREPARING LIQUID CRYSTALS Rolic AG (CH) 2000-06-28 EP disclosed
WO-1999012920-A1 MONOACETALS OF BICYCLOHEXYL-4,4-DIONE AND THEIR USE IN PREPARING LIQUID CRYSTALS ROLIC AG (CH) 1999-03-18 WO disclosed