Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678534 | 0.91 | MAPT (0.48) | MAPTLMNATP53CNR1EPHX2 | |
| SCHEMBL6670431 | 0.89 | ALDH1A1 (0.51) | MAPTLMNAEPHX2HDAC4HDAC1 | |
| SCHEMBL6680500 | 0.84 | MAPT (0.47) | MAPTLMNATP53CNR1EPHX2 | |
| SCHEMBL6684875 | 0.84 | MAPT (0.49) | MAPTLMNATP53CNR1PPARG | |
| SCHEMBL6684559 | 0.83 | MAPT (0.53) | MAPTLMNATP53CNR1PPARG | |
| SCHEMBL6665661 | 0.81 | ALDH1A1 (0.51) | MAPTLMNATP53CNR1HDAC8 | |
| SCHEMBL6679778 | 0.80 | MAPT (0.47) | MAPTLMNATP53CNR1PPARG | |
| SCHEMBL6683273 | 0.79 | MAPT (0.49) | MAPTLMNATP53CNR1HDAC8 | |
| SCHEMBL6664618 | 0.79 | ALDH1A1 (0.53) | MAPTLMNAEPHX2HDAC4HDAC1 | |
| SCHEMBL6681366 | 0.79 | MAPT (0.56) | MAPTLMNATP53CNR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014388-A1 | 6,6-FUSED HETEROARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |