Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.44 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6668601 | 0.93 | SMO (0.46) | SMOEIF2AK3LRRK2ALDH1A1MAPT | |
| SCHEMBL6805248 | 0.92 | SMO (0.47) | SMOEIF2AK3NPSR1CYP3A4ALDH1A1 | |
| SCHEMBL6667958 | 0.91 | SMO (0.44) | SMOEIF2AK3 | |
| SCHEMBL6803877 | 0.87 | SMO (0.47) | SMOEIF2AK3NPSR1ALDH1A1MAPT | |
| SCHEMBL6665157 | 0.86 | SMO (0.49) | SMOEIF2AK3RAB9A | |
| SCHEMBL6664878 | 0.86 | EIF2AK3 (0.48) | SMOEIF2AK3MAPTRAB9A | |
| SCHEMBL6663993 | 0.86 | EIF2AK3 (0.50) | SMOEIF2AK3RAB9A | |
| SCHEMBL6664314 | 0.86 | SMO (0.47) | SMOEIF2AK3CYP1A2 | |
| SCHEMBL6661936 | 0.86 | SMO (0.47) | SMOEIF2AK3ALDH1A1MAPTCYP1A2 | |
| SCHEMBL6664409 | 0.85 | EIF2AK3 (0.48) | SMOEIF2AK3ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |