SCHEMBL6665693

SCHEMBL6665693

CCCCCCc1cc2c(cc1C#Cc1ccc(CCCCC(=O)OCC)o1)C(C)(C)CCO2

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.35
HNF4A P41235 1/20 0.35
CYP4F2 P78329 1/20 0.34
CYP4A11 Q02928 1/20 0.34
ACHE P22303 4/20 0.33
EPHX2 P34913 1/20 0.32
ALDH1A1 P00352 1/20 0.32
PRKCA P17252 3/20 0.31
PPARG P37231 1/20 0.31
PPARA Q07869 1/20 0.31
GNRHR P30968 1/20 0.30
CNR2 P34972 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6669164 0.94 RXRA (0.36) RXRAHNF4ACYP4F2CYP4A11GNRHR
SCHEMBL7655957 0.91 CYP4F2 (0.33) CYP4F2CYP4A11ACHEEPHX2ALDH1A1
SCHEMBL6665834 0.89 RXRA (0.37) RXRAHNF4ACYP4F2CYP4A11GNRHR
SCHEMBL6667740 0.89 RXRA (0.33) RXRAHNF4AACHEEPHX2ALDH1A1
SCHEMBL8865633 0.87 CYP4F2 (0.34) CYP4F2CYP4A11ACHEEPHX2ALDH1A1
SCHEMBL6666819 0.86 RXRA (0.35) RXRAHNF4ACYP4F2CYP4A11
SCHEMBL6667736 0.86 RARA (0.37) CYP4F2CYP4A11ACHEEPHX2PRKCA
SCHEMBL6664926 0.85 CYP26A1 (0.37) RXRAHNF4AEPHX2ALDH1A1
SCHEMBL7660373 0.85 CYP4F2 (0.33) CYP4F2CYP4A11
SCHEMBL6668820 0.84 RXRA (0.35) RXRAHNF4ACYP4F2CYP4A11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0785782-B1 USE OF DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY ALLERGAN INC (US) 2004-09-08 EP disclosed
EP-0785782-A1 DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY Allergan (US) 1997-07-30 EP disclosed
US-5602130-A ORNITHINE DECARBOXYLASE ENZYME INHIBITOR TREATING SKIN DISORDER, INHIBITING CELL HYPERPROLIFERATION ALLERGAN 1997-02-11 US disclosed
WO-1996011686-A1 DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY ALLERGAN (US) 1996-04-25 WO disclosed
US-5380877-A Psoriasis treatment; retinoic acid-like activity ALLERGAN, INC. (US) 1995-01-10 US disclosed
US-5354752-A A dimethylthiochroman or dimethylchroman-6-yl-ethynyl-pyridazin- or pyrimidin- or pyrazin-for treating skin disorders psoriasis ALLERGAN, INC. (US) 1994-10-11 US disclosed
US-5348972-A In treatment of skin disorders such as acne and psoriasis ALLERGAN, INC. (US) 1994-09-20 US disclosed
US-5234926-A Skin disorders ALLERGAN, INC. (US) 1993-08-10 US disclosed
EP-0284288-B1 DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID LIKE ACTIVITY ALLERGAN, INC (US) 1992-05-27 EP disclosed
US-5089509-A Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity ALLERGAN, INC. (US) 1992-02-18 US disclosed
EP-0284288-A1 Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity ALLERGAN, INC (US) 1988-09-28 EP disclosed