Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 11/20 | 0.44 |
| ▸ | MTTP | P55157 | 11/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805186 | 0.91 | MTTP (0.49) | APOBMTTPSMOMAPTKDM4E | |
| SCHEMBL6669784 | 0.86 | SMO (0.53) | APOBMTTPSMOHTR2AHTR2C | |
| SCHEMBL6666524 | 0.81 | SMO (0.51) | APOBMTTPSMOHTR2AHTR2C | |
| SCHEMBL6663893 | 0.80 | APOB (0.45) | APOBMTTPSMOKDRALOX5 | |
| SCHEMBL6666569 | 0.80 | SMO (0.44) | APOBMTTPSMOKDRHTR2A | |
| SCHEMBL6667492 | 0.79 | NOTUM (0.60) | APOBMTTPHTR2AHTR2CMAPT | |
| SCHEMBL690395 | 0.78 | MTTP (0.51) | APOBMTTPSMOKDRMAPT | |
| SCHEMBL6664413 | 0.77 | HTR2A (0.42) | APOBMTTPSMOHTR2AHTR2C | |
| SCHEMBL6804857 | 0.77 | SMO (0.64) | APOBMTTPSMOHTR2AHTR2C | |
| SCHEMBL6809752 | 0.77 | MTTP (0.48) | APOBMTTPSMOMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |